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Contrave (naltrexone/bupropion) and Wegovy (semaglutide) are prescription drugs that can help adults manage their weight
GLP-1 receptors are expressed not only in pancreatic beta cells but also in various tissues including the cardiovascular system, kidneys, and immune cells such as macrophages and lymphocytes
Looking into the actual prescriber of the GLP-1 drugs is also critical for Minnesota
Researchers became interested in this combination because early studies suggested that adding amylin pathway modulation to triple incretin agonism could produce synergistic effects beyond either component alone similar to how the CagriSema (cagrilintide + GLP1) combination outperformed individual components in clinical trials
MS contributed to study design, collected and analyzed data, and wrote the manuscript
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