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For side effect management, doctors can recommend dietary changes, timing adjustments, or complementary medications to reduce discomfort

1 However, many patients stop taking GLP-1s within the first year of treatment due to side effects, cost, insurance barriers, or clinical decisions

Existing Health Conditions and Medication Factors Underlying conditions such as diabetes, previous urinary infections, kidney concerns, or certain medicines may also influence urinary symptoms during treatment

By reducing the removal of these molecules, the amount of active dopamine and norepinephrine is increased, helping people feel their positive effects longer. The same properties that can improve depression symptoms may also help with weight loss, since dopamine and norepinephrine stimulate certain neurons in the brain that suppress your appetite and improve satiety, Poplin says