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The dependence of tyrosine hydroxylase on BH 4 necessitates the coupling to the action of dihydropteridine reductase (encoded by the QDPR gene: quinoid dihydropteridine reductase) as is the situation for tryptophan hydroxylase (see below) and phenylalanine hydroxylase
One unit on the syringe equals 0.01 mL
Normal reduced glutathione powder might break down before it gets into the system
The two core mechanism papers were retracted in April 2025 (PMID 22129598, retraction notice PMID 40312092
No safety data exists for use during pregnancy
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