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6.2 Defining GLP-1RA-specific cellular mechanisms Key mechanistic questions remain unresolved, including how GLP-1RAs modulate monocyte-to-macrophage differentiation, macrophage polarization (M1M2), foam-cell formation, and cholesterol efflux within atherosclerotic lesions
Why These Concerns May Not Apply to Humans Although these animal studies raised red flags, human physiology suggests that the findings in rodents may not apply to humans
The SELECT trial showed Wegovy reduces heart attacks and strokes by 20%
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