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Once a glucuronidated conjugate is excreted into bile and reaches the intestine, certain gut bacteria produce an enzyme called beta-glucuronidase that cleaves the glucuronic acid group, liberating the original compound for reabsorption

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This was born out of anecdotal experience of the limited number of aborted procedures we experienced before the ASA statement. Her group also hypothesized that the indication for which the GLP-1 RA was prescribed would be important, with patients taking GLP-1 RA medications for diabetes potentially having a higher likelihood of retained contents given the concomitant propensity for delayed gastric motility related to uncontrolled hyperglycemia

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