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Based on the known class profile of GLP-1 and glucagon receptor agonists, the following additional risks are relevant: Pancreatitis: Severe and persistent abdominal pain, particularly if it radiates to the back and is accompanied by vomiting, may indicate pancreatitis
before dispensing
Also worth noting: A 2025 study that compared FDA Adverse Event reports that people are less likely to report acute kidney injury with tirzepatide than with semaglutide
Caroline Apovian, co-director of the Center for Weight Management and Wellness at Brigham and Womens Hospital in Boston
Other conditions showing signals Emerging research suggests potential benefit in gout (reduced risk of development in GLP-1 users), osteoarthritis (improved joint outcomes in semaglutide users), and endometriosis (anti-inflammatory mechanisms relevant to endometrial inflammation)
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