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These drugs are essential to prevention of rejection but come at a metabolic cost, disrupting glucose metabolism through several mechanisms, including downregulation of transcription of the adiponectin gene which can lead to greater risk for glucose intolerance

Skin Discoloration : Darkening or discoloration of the skin around the veins, indicating potential complications such as venous insufficiency or ulceration

Therefore, substantial weight loss achieved with GLP-1 receptor agonists could meaningfully reduce joint discomfort

doi: 10.2196/38000 66 FischerAZhangLElbjiAWilmesPOustricPStaubTet al

However, the E value calculation showed that to explain away the observed associations of GLP-1 RAs use and DR, an unmeasured confounder would need to have an HR of 4.19 with both GLP-1 RAs use and DR