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Moreover, digital endpoints (e.g., gait variability, voice modulation, tremor amplitude) using AI analytics offer objective and continuous monitoring over traditional scales like the Unified Parkinsons Disease Rating Scale (UPDRS)

As research on transcription and translation advanced, it was discovered that initial RNA transcripts typically require intron removal and the linkage of exons to form mature messenger RNA (mRNA), a process known as RNA splicing

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Finally, they reflect pathways likely additional to those involved in the angiogenesis (Vukojevic et al., 2018), recently associated in particular with the increased expression, internalization of VEGFR2, and the activation of the VEGFR2-Akt-eNOS signaling pathway (Hsieh et al., 2017) (see Genes Expression as Support ), given the rapid presentation of all of these effects, which occurred before the process of angiogenesis could be initiated (Sikiric et al., 1993