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Without these controls, high-cost therapies can be approved and dispensed without any plan-level review of whether a lower-cost alternative exists

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The report was uncontrolled, unblinded, not randomized, had no comparator arm, used patient-reported outcomes rather than validated pain instruments, and did not publish dose, effect size, confidence intervals, p-values, or systematically collected adverse events limitations that severely constrain any clinical inference

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Excess cellular senescence is thought to be one cause of many diseases of aging.[ref] Epidemiological studies tie high taurine levels in traditional Japanese diets to their longevity and healthspan.[ref] More recent studies showing healthspan and longevity benefits used supplemental taurine in amounts equivalent to 3-6 grams per day for an average adult

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