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While certain GLP-1 medications are approved for diabetes and weight loss by the US Food and Drug Administration (FDA), most off-label semaglutide medications are compounded GLP-1s, which are not FDA-approved

Discontinuation In Phase 2, 6-16% of participants stopped because of adverse events versus 0% on placebo

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This is actually advantageous for widespread eczema, where applying topical treatments to large body surface areas is impractical and compliance-limited