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Several studies have indicated that the presence of S aggregates in the gut can spread out to the brain via the vagus nerve ( S has a high binding affinity for pre-synaptic vesicles and its accumulation in pre-synaptic terminals is a sign of synaptopathy

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Cognitive and neurological effects also warrant caution

Deficiency correction (B12): The B12 component reliably corrects deficiency-related fatigue and anemia, but has no documented energy or weight effect when B12 status is already normal [2]