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Participants received once-daily subcutaneous semaglutide at doses of 0.1 mg (80 patients), 0.2 mg (78 patients), 0.4 mg (82 patients), or placebo (80 patients)

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Following reports that certain antihyperglycemic agents increased CV events [16, 17], the FDA issued new guidelines in 2008 requiring that drug developers perform comprehensive assessment of CV safety on any new diabetes drug to ensure that these therapies do not increase the risk of CV events

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