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And PE is able to establish hydrogen bonds with a variety of amino acid residues, which in turn inhibits the localization of negative amino acids on the cytoplasmic side, and is an important determinant of the topology of transmembrane structural domains of membrane proteins (Shi et al., 2024)

Notably, all these experimental studies have certain limitations in their design

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The substantial interindividual variability in SFN bioavailability, driven by differences in gut microbiota composition and GST polymorphisms, necessitates personalized dosing strategies (100, 101)

Wu, B., Zeng, Z., Wu, X., Li, Yi., Wang, F., Yang, J., and Li, X., Jasmonic acid negatively regulation of root growth in Japonica rice ( Oryza sativa L.) under cadmium treatment, Plant Growth Regul