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The studies varied in design, patient population, and outcome measures, making direct comparisons challenging

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An essential role of interleukin-1beta in mediating NF-kappa B activity and COX-2 transcription in cells of the blood-brain barrier in response to a systemic and localized inflammation but not during endotoxemia

it documents a claimed invention and supporting examples, but it does not undergo the independent scrutiny, pre-registration, blinding, and statistical reporting that define credible clinical evidence