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So far, eight isoforms of Gpx have been identified in humans, which vary in cellular location and substrate specificity (Mari et al., 2009), which in the liver account for about one third of the total Gpx activity ( 2 O 2 and has been classically believed to be the major H 2 O 2 reducing enzyme

Under conditions of oxidative stress, GSH is oxidised to GSSG, thus the ratio of GSH: GSSG is altered

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Or three 10mg vials (weeks 1-8) plus three 30mg vials (weeks 9-16)