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The GLP-1 analog, exenatide, reduced mucin production by restoring FOXA2 function through the activation of GLP-1 receptor-peroxisome proliferator-activated receptor gamma (PPAR-)-phosphatase and tension homolog (PTEN) signaling in COPD-derived human primary bronchial epithelial cells [114]

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Highly palatable, high-calorie foods typically trigger a significant dopamine release, creating a pleasurable sensation that encourages repeat consumption