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With respect to the prescription of semaglutide for ensuring weight management, Health Canada has given approval to the 2.4 mg of injection to serve as a measure to be implemented in addition to a reduced calorie diet and increased activity to manage weight in patients having: A BMI of 30 kg/m2 or higher (obesity) A BMI of 27 kg/m2 or higher (overweight) In addition to this, it is also expected that the patient should suffer from chronic weight-related issues, like dyslipidemia, hypertension, or obstructive sleep apnea

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Managing Potential Side Effects Pioglitazone Side Effects Fluid retention and swelling (edema) are common with TZDs

14 , e1007171 (2018)

Patients with impaired kidney function may experience elevated drug concentrations if dosage adjustments are not implemented