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Circulation 2017;136:1643-1658

The findings indicated that metformin treatment led to enhanced endometrial tolerance through the downregulation of tolerance-related miRNAs, specifically miR-1910-3p and miR-491-3p, resulting in elevated expression of endometrial tolerance markers HOXA10 and ITGB3 in patients with PCOS

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Interestingly, the trial also revealed a positive correlation between dulaglutide treatment and a reduced risk of cognitive impairment