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Patients on GLP-1 medications experience fat loss to varying degrees, and because cheek volume depends on both fat and collagen, that loss can make the face look flatter or more deflated faster than typical aging alone, says New York dermatologist Jane Yoo, MD

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Common types of dermal fillers include hyaluronic acid-based fillers, calcium hydroxylapatite, poly-L-lactic acid, and polymethylmethacrylate

-Ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice