As we move into the 5th year of GLP-1 medical management, we have discovered that we can do more to support fitness while shedding weight safely
Understanding why this happens requires looking at both the pharmacology of the drug and the broader context of each person's health, lifestyle, and treatment journey
Meet our doctors Last reviewed: 19 Jun 2026 Sources Effectiveness of Dulaglutide in the Real World and in Special Populations of Type 2 Diabetic Patients (2020) NIH [accessed 27 January 2026] Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial (2023) The Lancet [accessed 27 January 2026] How to use Mounjaro (2023) Mounjaro [accessed 27 January 2026] Lillys SURMONT-2 results published in The Lancet show tirzepatide achieve a mean weight reduction of 15.7% at the highest dose (15mg) in adults with obesity or overweight and type 2 diabetes (2023) Lillys INVESTORS [accessed 27 January 2026] MHRA authorised diabetes drug Mounjaro (tirzepatide) for weight management and weight loss (2023) GOV.UK
In a manually reviewed sample of 288 people classified as discontinuers, cost or insurance was the documented primary reason for 137, side effects for 42, and shortages for 34
Our weight loss program in Midland, Texas uses medications as an additional means to achieve and maintain a healthy weight when used under the guidance of a healthcare professional