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Alternatives include orlistat (though it may cause gastrointestinal side effects), structured lifestyle programmes with dietetic support, psychological interventions, tailored physical activity, and bariatric surgery for eligible patients

Franks Weight Loss Clinic, who was not involved in this study, spoke with MNT about the results

Conclusion: Tirzepatide demonstrates superior metabolic efficacy in direct comparative trials, whereas semaglutide currently has the strongest evidence for cardiovascular benefit

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