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Though the absolute risk appears to be small, more study is warranted to confirm whether GLP-1s can negatively affect some peoples sense of smell and taste, the researchers say

The VDR agonist paricalcitol has demonstrated multitarget antifibrotic effects in experimental models

Thats because our bodies are so good at getting enough (even from our bones) that calcium levels tend to show up as normal even when theres an issue

Furthermore, studies have shown anti-inflammatory and antioxidant activity [31]

This may be more prevalent in the control group, leading to a reduced differential of weight loss between the control and intervention arm