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Hence, because some of the cardiovascular benefits of SGLT2is are related to their hemodynamic effects, while those of GLP-1RAs are mainly related to their anti-atherogenic/anti-inflammatory actions, the two classes of medications may produce an additive cardiovascular benefit [11]

The underreported symptoms are leads that came from patients themselves, unprompted, and clinicians could potentially pay attention to them. Clinical trials generally identify the most dangerous side effects of drugs, adds Lyle Ungar, Professor in CIS and a co-author on the study