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While highly effective, it presents a distinct side effect profile including gastrointestinal issues and dysesthesia, leading to a slightly higher discontinuation rate in studies

Maintenance protocols using 0.160.25mg administered 23 times weekly sustain approximately 7085% of peak pigmentation indefinitely without adverse events

Many people experience nausea, vomiting, diarrhea, or constipation when they first start taking the medication

The only GLP-1 based treatments proven to support weight loss in the UK are prescription-only medications that have been approved by regulators such as the Medicines and Healthcare products Regulatory Agency (MHRA)

These typically improve as the gut adapts over 1-2 weeks