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FIGURE 6 In summary, GPX7 is an essential sensor for oxidative stress and endoplasmic reticulum stress ( 2.8 GPX8 Glutathione peroxidase 8 (GPX8) is a type II transmembrane protein with rare structural features that consists of 209 amino acids (Yoboue et al., 2017)

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The initiation of ferroptosis involves the depletion of GSH, an essential cellular antioxidant, which leads to the accumulation of toxic lipid ROS and eventual cell death (Tang et al., 2021)