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The proposed mechanism most relevant to surgery is angiogenesis the formation of new blood vessels
Read review Dihexa for Endometriosis Brain Fog The November 2025 Lancet O&G/WH 'overlooked symptom' commentary from Edinburgh EXPPECT, the April 2025 Horn FACT-Cog 1,239-patient survey (~80% perceived cognitive impairment), the March 2025 NICE TA1057 Ryeqo approval (first daily pill on NHS), the April 2024 NICE NG73 update, the April 2026 renewed Womens Health Strategy with 117 action points, the 2023 Greaves CNS-wide glial activation mouse model, the BDNF/TrkB central-sensitisation directionality paradox, and the ~1.5 million UK women affected
In PD, peripheral immune cell infiltration triggers a neuroinflammatory cycle that includes BBB disruption, -syn-driven innate immune activation, and adaptive immune-mediated cytotoxicity
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Amylin signaling produces satiety, slows gastric emptying through a distinct mechanism, and reduces postprandial glucagon
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