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Further, controlled clinical studies simulating NSW provide causal evidence that melatonin secretion diminishes rapidly upon night work exposure and remains suppressed with continued circadian disruption 183

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Among these antagonists free of edematogenic effects, [Ac-d-Nal(2)1, d-Phe(4Cl)2, d-Pal(3)3, d-Cit6, d-Ala10]LH-RH (SB-75), designated cetrorelix [Cetrotide], had high activity, and was synthesized first in our laboratory 20 and later also made by Zentaris 21