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Like liraglutide and semaglutide, tirzepatide is currently contraindicated for patients with either a personal or family history of MTC and for patients with MEN 2
They reduce caspase-3 mRNA activity and enhance the expression of anti-apoptotic genes, including Bcl-2 and Bcl-xl [45, 46]
These in vitro findings support the notion that ALC decreases cholesterol synthesis by downregulating SREBP2, thereby contributing to its lipid-lowering effects observed in vivo
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Inoue A, Jiang L, Lu F, et al
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