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Lu B, Lee J, Nie X, Li M, Morozov YI, Venkatesh S, et al
5. What are the Side Effects
Drug Interaction Studies Clinical Studies and Model-Informed Approaches: The delay of gastric emptying with semaglutide may influence the absorption of concomitantly administered oral drugs
In conclusion, while reduced GLP-1 levels have been described individually in some participants as well as in groups with type 2 diabetes mellitus, this does not seem to be a universal characteristic that is representative of all patients
These benefits are reflected in the clinical guidelines published by the American Diabetes Association (ADA) and the American Association of Clinical Endocrinologists/American College of Endocrinology (AACE/ACE), which recommend use of a GLP-1RA or a sodium-glucose co-transporter-2 inhibitor (SGLT2i) with demonstrated CV risk reduction in patients with established/high risk of atherosclerotic CVD (ASCVD), while considering patient-specific factors [15, 17]
