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In the human heart, cardiomyocytes occupy approximately 70 to 85% of the cardiac volume [19]
In this work we used a C73S hTrx1 mutant in order to avoid formation of hTrx1 dimers involving a disulphide between Cys73 hTrx1 and C73 hTrx1 of a second hTrx1 molecule 26,27
Intriguingly however, very recent data on anti-CD20 B cell depleting agents might be showing some efficacy in progressive MS, although the effect of peripheral B cell depletion on PIRA cannot be interpreted as independent of its effect on silencing acute/adaptive inflammatory activity (Kappos et al., 2020)
Biophysics of alpha-synuclein membrane interactions
