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REDEFINE-1: adults with obesity, no diabetes Design: 3,417 adults with BMI 30 (or 27 with a comorbidity), without type 2 diabetes, for 68 weeks
doi:10.2174/13816128113190990411
In an eight-year follow-up study, no serious immediate or long-term complications attributable to spironolactone for treatment of acne were reported.[48] Still, mild side effects were present in 59 percent of the subjects, with menstrual irregularity being among the most common.[48] Hyperkalemia is often discussed as a potential concern
However, increased potency requires vigilance
Water weight typically sheds quickly, and the scale often drops noticeably within a few days
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