The FDA has not said when it would announce a decision about weight loss approval for Mounjaro, but consensus expectations place it sometime in Q4 23 = Q1 24
TRIUMPH-3 was not designed or powered to measure cardiovascular outcomes -- that is the job of the separate, event-driven TRIUMPH-Outcomes trial (NCT06383390)
In a metabolism trial, semaglutide was the primary component circulating in plasma and, prior to excretion, it was metabolised by proteolytic cleavage of the peptide backbone and sequential beta-oxidation of the fatty acid side chain [4]
For those with IBS-D (diarrhoea-predominant IBS), there can be some improvements in bowel urgency and/or frequency
At week 72, most (95.3%) of the participants with prediabetes at baseline in the tirzepatide groups had reverted to normoglycemia, as compared with 61.9% of participants in the placebo group