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Offspring effects included lower pup survival after birth, increased limb and tail malformations, reduced pup body weight and delayed growth, development, and sexual maturation without affecting learning, memory, or fertility and reproduction

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The down-regulation of PGC-1 further inhibits the expression of downstream factors such as nuclear respiratory factor 1 and mitochondrial transcription factor A, thereby damaging the mitochondrial biosynthesis process, which is often accompanied by an increase in the oxidative stress levels [31]

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