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It works as a dual GIP/GLP-1 receptor agonist, activating two hormone pathways simultaneously rather than just one

Measured Percent body-weight change at 24 and 48 weeks

Before each injection, always clean the rubber stopper on the vial and the injection site on your skin with an alcohol swab to prevent infection

Studies show that injecting MT2 into specific hypothalamic nuclei (like the ventromedial hypothalamus) increases glucose uptake in peripheral tissues, helping researchers map distinct hypothalamic roles in glucose regulation

This also depends on how your body reacts to the medication, but clinical trials showed that after 24 weeks (around six months), the average participant on higher doses of retatrutide lost close to 18% of their body weight