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many patients continue treatment with monitoring Single episode of biliary colic: usually an indication for cholecystectomy, after which GLP-1 therapy can typically continue uninterrupted Acute cholecystitis or other complication: urgent surgical management, with GLP-1 therapy paused and reintroduced after recovery The decision is individualised and made jointly with your prescribing clinician

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Bissett DL et al

Clinical perspective: The first question isn't just Are you tired? It's What kind of tired are you having, when did it start, and what else changed at the same time? That distinction helps guide what to do next