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Science 385 , eadj1182 (2024)

Its interaction with dopamine signaling is the central pharmacodynamic concern when combining it with amphetamine-based medications

Schachner-Nedherer, A

Digestive discomfort and mild irritation at the injection site were among the most commonly reported side effects

Behavioral intervention consisted of counseling by a dietitian or similarly qualified healthcare professional every 4 weeks via in-person visits or telephone on adherence to a reduced-calorie diet (500 kcal deficit a day relative to the energy expenditure estimated at randomization) and increased physical activity (150 minutes a week encouraged, for example, walking), both recorded daily (via a diary, app or other tools, which were reviewed during counseling sessions)