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For arthritis specifically, semaglutide has evidence from the STEP-9 knee osteoarthritis trial and studies on rheumatoid arthritis joint outcomes, while tirzepatide has shown roughly a 33% reduction in hsCRP and an 18% reduction in IL-6 (key inflammation markers) in meta-analyses
The restriction on government insurance applies to manufacturer savings cards not pure cash-pay programs like LillyDirect
After applying the defined PICOS inclusion and exclusion criteria to select studies directly comparing tirzepatide and semaglutide, a total of 10 studies were deemed eligible for this review
For patients with existing heart disease, semaglutide's proven CV benefit is a major differentiator
Safety and Quality : Semaglutide is a pharmaceutical-grade medication, while OTC supplements can vary widely in quality and safety
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