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The observed improvement arose via two synergistic effects: (1) direct non-covalent interactions of Y218 with the PET substrate, and (2) the subsequent enhancement in enzyme-substrate binding affinity
& Steller, H
R.ElsbyR.RandleL
Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy
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