Medical Considerations: Semaglutide or Tirzepatide, including micro-dose programs, cannot be prescribed and should not be purchased by individuals with a BMI under 25 (or under 20 for micro-dosing), an eating disorder, diabetes, gallbladder disease, history of drug or alcohol abuse, recent bariatric surgery, pancreatitis, medullary thyroid cancer or a family history of it, diabetic retinopathy, multiple endocrine neoplasia type 2, or those who are pregnant, breastfeeding, or planning to become pregnant
The drugs have large molecules that make that very difficult, if not impossible, he notes
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These observations suggest that obesity in KOA is not merely a background characteristic but a biologically and clinically relevant disease driver
J Clin Endocrinol Metab dgae722 Klonoff DC, Buse JB, Nielsen LL, Guan X, Bowlus CL, Holcombe JH et al (2008) Exenatide effects on diabetes, obesity, cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes treated for at least 3 years