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An increase in oxidative stress and cell damage causes an increased usage of glutathione and decreased levels
J Biol Chem 280 , 2528425290 (2005)
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Glutamyl-transpeptidase catalyzes the condensation of glutathione and the disulfide cystine to form gamma-glutamyl-cystine, which is then taken up and reduced intracellularly to form cysteine and gamma-glutamyl-cysteine (49)
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