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Activation of GLP-1R by GLP-1 or other exogenous agonists, including exendin-4 and liraglutide, decreases inflammatory responses in several animal models like rat heart and whole animal model

Esculentoside A induces mammary CSC apoptosis by blocking the expression of IL-6 and STAT3 pathway proteins and the up-regulation of caspase-3 and Bax/Bcl-2 ratio (156)

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Mechanism and safety of AOD 9604 Jul 202022 AOD 9604 is FDA approved and often marketed as an anti-obesity drug

The mutation of GLP-1 Phe 28 to Ala causes it to lose nearly all of its affinity (IC 50 : 0.27 nM357 nM), and Ile 29 mutation decreases the affinity notably (IC 50 : 0.27 nM25 nM), while Trp 31 , Leu 32 , and Val 33 mutations have little influence, showing that they may be merely subsidiary