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They found that for FDA approved GLP-1s for weight loss, liraglutide (Saxenda) and semaglutide (Wegovy), the percent of side effects reported was as follows: Nausea: 42.2% Diarrhea: 21.9% Vomiting: also 21.9% Constipation: 8.4% They report that although the incidence of side effects were similar among medications, semaglutide had the greatest risk of nausea, diarrhea, and vomiting, whereas liraglutide had the greatest risk of upper abdominal pain
Nevertheless, PE-based aqueous formulations require very high volumes to accommodate the large amount of PE per dosage unit, considering the limited PE water solubility in low-to-mid pH environment [18]
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Serious side effects are rare, but its important to consult with a healthcare provider to ensure that peptide therapy is appropriate for you and to discuss any potential risks
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