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doi:10.7570/jomes21071 Fletcher MM, Keov P, Truong TT, et al
By activating the cGMP/PKG signaling pathway, it can reversibly and locally open the tight junctions of intestinal epithelial cells, thereby enhancing drug delivery efficiency by 3.5-fold and achieving a therapeutic efficacy of 98.6% in treating CRC
Surface marker staining (CD45, CD3, CD4, CD8, CD11c, CD86 and CD80) was performed at 4 C in the dark for 30 min
Most adverse events were gastrointestinal and mild or moderate in severity
The determination of the optimal and appropriate duration of selenium supplementation for GD, as well as the proper selection of the most appropriate prebiotic compound and the required Prebiotic Index (PI), which could at best be obtained by matching certain prebiotics with certain probiotic species, optimized in each patient
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