Copper overload can affect the methylation pathway, which can have a domino effect on various other systems in the body
Patients considering glutathione treatment should understand both mechanism and evidence quality before starting
Biochemistry 47 , 1114411157 (2008)
R471C has been shown to localise to the membrane and has ~15% activity of wildtype OCTN2 in CHO cells, which is consistent with the observed reduction in currents for R471A, meanwhile Y358N in CHO cells has ~8% activity, though localisation data for Y358N is unavailable 11,50
Acetyl-L-carnitine is involved in protein acetylation Development, Cell Differentiation and Cancer 1996, 9th International Conference ISD, Pisa, Italy Swamy-Mruthinti S, Carter AL