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Healthcare providers should prepare patients for potential nausea, headaches, and gastrointestinal symptoms

FDA-approved medications containing semaglutide are available

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In addition, casecontrol studies integrating microbiome profiling with systemic immune markers have demonstrated correlations between altered microbial genera and elevated pro-inflammatory cytokines (e.g., IL-6, IFN-, TNF-), supporting a link between gut dysbiosis and systemic immune activation in PD [197]