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Systemic administration produced equally impressive results: in cardiac ischemia models, doses ranging from 400 ng to 15 mg per animal reduced infarct size, improved myocardial function, and enhanced survival through activation of integrin-linked kinase and Akt pathways promoting cardiac cell migration and angiogenesis while preventing excessive fibrosis
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Tissue Repair and Recovery Research Tissue repair is one of the more substantiated research areas for IGF-1 LR3, largely because the underlying mechanisms collagen synthesis stimulation and satellite cell recruitment are directly relevant to muscle and connective tissue recovery
PMID 15990954
The sleep inducing effects of melatonin are the result of the activation of MT 1 in the suprachiasmatic nuclei (SCN) within the hypothalamus
