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Oxidative stress is crucial in atherogenesis (144151), suggesting that a specific antioxidant/prooxidant imbalance, characterized by a weak GSH-related enzymatic antioxidant shield present in human atherosclerotic lesions, may be involved in atherogenic processes in humans (152)
Evidence boundary No human clinical trial has tested cagrilintide + tirzepatide together
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CagriSema clinical trial results The REDEFINE 1 trial enrolled adults with obesity or overweight (BMI of 30 or greater, or 27 or greater with at least one weight-related comorbidity) without type 2 diabetes
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