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doi: 10.1038/nrendo.2012.140 35 FriasJPNauckMAVanJKutnerMECuiXBensonCet al

Results Across mechanistic endpoints, LC was associated with reductions in inflammatory markers, oxidative stress indices, and cardiac injury biomarkers, with several trials noting improvements in left-ventricular function and lipid profiles

Accordingly, CB 1 receptor antagonism is associated with enhanced insulin sensitivity, improved metabolic outcomes, and weight loss 61

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For cardiologists managing post-MI, stroke, and PAD patients, this is no longer optional