Furthermore, fertility testing of fluoxetine-treated male rats was not performed to directly assess its effects on reproductive function, and the study only employed animal models and did not explore the relevance of the findings for human patients
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Unlike skeletal muscle and heart, which predominantly express Ca 2+ -sensitive isoforms, other tissues, in particular pancreatic islets, have significant expression of Ca 2+ -independent OGDH isoforms, which are thought to be involved in the distribution of 2-oxoglutarate flux to oxidation in the TCA cycle and glutamate biosynthesis (40)
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