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In terms of the primary outcome of reduction in A1C from baseline, although the 3-mg oral semaglutide group did not demonstrate superiority to sitagliptin 100 mg at 26 weeks, the 7-mg and 14-mg dosage groups did demonstrate statistically significant reductions in A1C from baseline when compared with sitagliptin

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This makes the feeling of fullness last longer

Some individuals have more responsive GLP-1 receptors in their hypothalamus (the brain region controlling hunger), leading to earlier appetite suppression